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Spray Drying

Life Sciences / Spray Drying

Leverage Pharmaceutical Spray Drying

Poor water solubility can prevent your drug product from achieving its full bioavailability potential. To overcome this barrier and optimize your drug’s efficacy, our expert team offers pharmaceutical spray drying for amorphous solid dispersions. This advanced technique effectively removes crystallinity and maximizes soluble concentration at the site of absorption.

Spray drying also proves to be an efficient way to produce protein solids for storage and incorporation into various formulations. These protein solids can be utilized in solutions, suspensions, and capsule or tablet configurations, expanding their potential applications and benefits.

To determine if spray drying is the right technology to enable your drug development program, our team evaluates its applicability across your product lifecycle, from early-stage development to commercialization. By leveraging our knowledge and expertise, we optimize your drug’s performance and help you overcome the limitations of poor water solubility.

Ready to see if spray drying is the missing piece to your small molecule puzzle?
Or Call: 612.656.1175

Improve Bioavailability

  • Amorphous Solid Dispersions
  • Isolation After Complexation or Microencapsulation
  • Rendering of Proteins into Dried Solids
  • Organic Solvent or Aqueous Modes
  • Closed Loop Systems with Nitrogen Purge
  • Two Fluid & Pressure Nozzle Configurations
  • Three Fluid Nozzle
  • Vacuum Oven Secondary Drying with Nitrogen Sweep
  • Downstream processing into Finished Drug Product
  • Feasibility: Gram Scale, Open and Closed Loop
  • Clinical/Pilot Scale: Kilogram Scale, Closed Loop
Spray Drying Equipment
  • GEA Spray Dryer Mobile Minor Closed Cycle
  • Buchi Spray Dryer B-290/295/296

Diverse Molecular Support

Small Molecules

Process usually involves spray drying with volatile organic solvents, which allows us to render amorphous, non-crystalline solids. We offer the option to add in functional excipients, e.g., polymers for physical stability and/or surfactants for wettability. This approach can offer advantages in speed and cost compared to lyophilization.


Biologics are also capable of being rendered a solid from a solution via spray drying. In this case, aqueous solutions are typically used instead of volatile organics. Biologics are more sensitive to heat of spray drying, so processes are in place to monitor the sample and mitigate the heat effect, if necessary.

Integrated Laboratory Services 

Leverage advanced technologies and comprehensive support when you partner with our team. Are you ready to uncover an innovative solution for your project?