Pace® offers small scale feasibility and current Good Manufacturing Practices (cGMP) pilot scale processes for bioavailability enhancement of orally administered small molecules.
Leverage our commercially proven approaches to boosting bioavailability for poorly water-soluble drugs through production of amorphous solid dispersions and nanoparticle dispersions. Our team can rapidly assess the feasibility of multiple bioavailability enhancement techniques when traditional approaches are not sufficient.
Connect with Pace® to learn how we can help enhance your small molecule.
Benefits Of Amorphous & Nanoparticle Dispersions
- Drastically increases dissolution rate and apparent drug solubility.
- Capable of providing multi-fold increases in drug bioavailability.
- Feasibility can be performed at gram scale making it suitable for early development.
- Proven commercial track record.
Development Of Amorphous & Nanoparticle Dispersions
- Lab and pilot scale capabilities for R&D and GMP processing.
- Capabilities to process solid dispersion intermediates into finished product.
- Biorelevant dissolution studies of solid dispersions.
- Solid state characterization of solid dispersions.
- Physical stability studies.
Technique | Equipment | Model | Type |
|---|---|---|---|
Spray Drying | Spray Dryer | Mobile Minor Closed Cycle | GEA |
Spray Dryer | B-290/295/296 | Buchi | |
Hot Melt Extrusion | Hot Melt Extruder | ZSE-18HP-e | Leistritz |
Hot Melt Extruder | ZSE-16 attachment | Leistritz | |
Loss-in-weight powder feeders (x2) | K-CL-24-KT20 | K-Tron | |
Micro Liquid Additive Injection System | Optos-Series | Eldex | |
Side Stuffer | LSB-17 | Leistritz | |
Chill Roll Cooler-Conveyor | AL-0810 | Leistritz | |
Air-Quench Cooling Take-off Unit | AL-06 | Leistritz | |
Dual Drive Stainless Steel Micro Pelletizer | Model 25 | Leistritz | |
Nanoparticles | High Efficiency Bead Mill | Dyno(R)-Mill ECM-AP 05 | WAB US Corp. |